The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Hironori Ueda, Joanna M. M. Howson, Laura Esposito et al. · Nature · 2003 · 2.2K citations · Full text

Immunogenetics, Autoimmune Disease, T-regulatory Cell +9

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

Alberto Pugliese, Markus Zeller, Alarico Fernandez et al. · Nature Genetics · 1997 · 944 citations

Type 1, Transcriptional Regulation, Allelic Variant +11

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

Petros Vafiadis, Simon T. Bennett, John A. Todd et al. · Nature Genetics · 1997 · 812 citations

Metabolic Syndrome, Human Thymus, Iddm2 Locus +10

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

Lorenza Nisticò · Human Molecular Genetics · 1996 · 801 citations · Full text

Mhc Genes, Belgian Diabetes Registry, Genetics +24

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

S. T. Bennett, Anneke Lucassen, Stephen Gough et al. · Nature Genetics · 1995 · 754 citations

Insulin Resistance, Metabolic Syndrome, Tandem Repeat Variation +11