Scandinavian Journal of Gastroenterology · 1987 · 36 citations · 6 references
PharmacyPharmacologyPharmacotherapyBioavailabilityExcretionMineral MetabolismDrug AbsorptionRenal DiseaseRenal Drug AbsorptionRenal EliminationRenal ExcretionUrinary ExcretionAluminum ExcretionAluminum In AntacidsRenal Failure ManagementRenal Function EvaluationRenal Function LossRenal Metal ExcretionUrinary Excretion KineticsUrinary Excretion Rate
Eleven subjects with normal renal function were given, on 2 separate days, at least 1 week apart, four tablets of sucralfate or an aluminium (Al)-containing antacid. The total Al load was approximately 976 mg with the antacid and approximately 828 mg with sucralfate. The daily urinary excretion of Al was measured the day before and during 3 days after drug administration. Al excretion increased significantly after both drugs. There was no significant difference between the two products. The median absorption calculated as percentage of Al dose was 0.005% (range, 0.001-0.017%) for sucralfate and 0.006% (range, 0.002-0.060%) for the antacid. Thus, measurable quantities of aluminium is absorbed after administration of sucralfate, and the drug should, like Al-containing antacids, be given with caution to patients with renal failure.
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Healing of benign gastric ulcer with low-dose antacids and fiber diet
Andreas Rydning, R. Weberg, Qve Lange et al. · Gastroenterology · 1986 · 54 citations