Gastrointestinal Absorption of Aluminum from Aluminum-Containing Antacids

Abstract

Specific tissue burdens of aluminum have been found to be increased in a number of conditions, and evidence has been presented that aluminum may be neurotoxic.1 , 2 The source of the aluminum has not been defined. An extensive review of biologic aspects of aluminum found no evidence to support absorption of orally administered aluminum compounds.3 Berlyne et al. indicated that serum aluminum levels did rise in uremic patients who ingested aluminumcycle resins.4 However, no definitive studies of changes in plasma and urinary levels in normal persons who ingest aluminum have been reported.Previous attempts to evaluate gastrointestinal absorption of aluminum were . . .