Serpin-1 splicing isoform J inhibits the proSpätzle-activating proteinase HP8 to regulate expression of antimicrobial hemolymph proteins in Manduca sexta

The serpin superfamily of proteinase inhibitors: structure, function, and regulation.

Jan Potempa, Edward Korzus, James Travis · Journal of Biological Chemistry · 1994 · 871 citations · Full text

Protein Chemistry, Protein Function, Protein Assembly +7

Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

James A. Irving · Genome Research · 2000 · 554 citations

Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient <i>Drosophila</i>

Elena A. Levashina, Emma Langley, Clare Green et al. · Science · 1999 · 435 citations

Toll-like Receptors, Molecular Immunology, Constitutive Activation +15

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the <i>Drosophila</i> Toll pathway

Nicolas Buchon, Mickaël Poidevin, Hyun‐Mi Kwon et al. · Proceedings of the National Academy of Sciences · 2009 · 220 citations · Full text

Innate Immune System, Immunology, Drosophila Toll Receptor +17

Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll

Laure El Chamy, Vincent Leclerc, Isabelle Caldelari et al. · Nature Immunology · 2008 · 218 citations · Full text

Inflammation, Toll-like Receptors, Pathways 'Upstream +11