Role of Phosphatidylinositol 3-kinase/Akt Pathway in Angiotensin II and Insulin-like Growth Factor-1 Modulation of Nitric Oxide Synthase in Vascular Smooth Muscle Cells

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Thomas Franke, Sung‐Il Yang, Tung O. Chan et al. · Cell · 1995 · 2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Roles for Insulin Receptor, PI3-Kinase, and <i>Akt</i> in Insulin-Signaling Pathways Related to Production of Nitric Oxide in Human Vascular Endothelial Cells

Guangyuan Zeng, Frederick H. Nystrom, Lingamanaidu V. Ravichandran et al. · Circulation · 2000 · 742 citations

Life Sciences, Cell Biology, Molecular Biology +13

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

Stephen R. James, C. Peter Downes, Roy Gigg et al. · Biochemical Journal · 1996 · 332 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

Michael J. Eck, Sirano Dhe‐Paganon, Thomas Trüb et al. · Cell · 1996 · 320 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo

Zhengyu Luo, Yasushi Fujio, Yasuko Kureishi et al. · Journal of Clinical Investigation · 2000 · 213 citations · Full text

Life Sciences, Pharmacology, Physiology +15