Effect of prostanoid EP4 receptor antagonist, CJ-042,794, in rat models of pain and inflammation

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.8K citations

Cent Inhibition, Inhibitory Activity, Biochemistry +8

Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention

Scott D. Solomon, John J.V. McMurray, Marc A. Pfeffer et al. · New England Journal of Medicine · 2005 · 2K citations · Full text

A method for measurement of analgesic activity on inflamed tissue.

Lowell O. Randall, Joseph J. Selitto · PubMed · 1957 · 1.6K citations

Inflammation, Health Sciences, Acute Pain +9

Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study

David J. Graham, David Campen, Rita L. Hui et al. · The Lancet · 2005 · 909 citations

Cardiovascular Disease, Medicine, Cyclo-oxygenase 2 +9

The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

Jennifer M. McCoy, Joan Wicks, Laurent Audoly · Journal of Clinical Investigation · 2002 · 353 citations · Full text

Immunology, Inflammatory Arthritis, Inflammation +19