Variants in CPA1 are strongly associated with early onset chronic pancreatitis

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

David C. Whitcomb, Michael C. Gorry, Robert A. Preston et al. · Nature Genetics · 1996 · 1.6K citations

Medicine, Genetics, Molecular Genetics +12

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

Heiko Witt, W. A. P. Luck, Hans Christian Hennies et al. · Nature Genetics · 2000 · 1K citations

Medicine, Molecular Genetics, Pathology +5

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

Jonas Rosendahl, Heiko Witt, Richárd Szmola et al. · Nature Genetics · 2007 · 435 citations · Full text

Medicine, Internal Medicine, Pathology +10

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

David C. Whitcomb, Jessica LaRusch, Alyssa M. Krasinskas et al. · Nature Genetics · 2012 · 360 citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis

Heiko Witt, W. A. P. Luck, Michael Becker · Gastroenterology · 1999 · 260 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +5