Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

David C. Whitcomb, Michael C. Gorry, Robert A. Preston, +12

Nature Genetics

Pancreatic CancerPancreatic Fluid CollectionGeneticsPathogenesisGastroenterology +6

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

Heiko Witt, W. A. P. Luck, Hans Christian Hennies, +5

Nature Genetics

Chronic PancreatitisPancreatic CancerPancreatic Fluid CollectionImmunologyGastroenterology +6

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

Jonas Rosendahl, Heiko Witt, Richárd Szmola, +30

Nature Genetics

Chronic PancreatitisPancreatic CancerPancreatic Fluid CollectionChymotrypsin CImmunology +4

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

David C. Whitcomb, Jessica LaRusch, Alyssa M. Krasinskas, +54

Nature Genetics

GeneticsPathogenesisGenetic EpidemiologySporadic PancreatitisPathology +2

A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis

Heiko Witt, W. A. P. Luck, Michael Becker

Gastroenterology

Chronic PancreatitisSignal TransductionMedicinePathogenesisImmunology +6

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

Heiko Witt, Miklós Sahin‐Tóth, Olfert Landt, +60

Nature Genetics

Pancreatic CancerPancreatic Fluid CollectionImmunologyGastroenterologyPathology +3

Hereditary pancreatitis caused by triplication of the trypsinogen locus

Cédric Le Maréchal, Emmanuelle Masson, Jian‐Min Chen, +4

Nature Genetics

Genetic DisorderPancreatic Fluid CollectionGeneticsPathogenesisHistopathology +4

<i>CFTR</i>, <i>SPINK1</i>, <i>CTRC</i> and <i>PRSS1</i> variants in chronic pancreatitis: is the role of mutated <i>CFTR</i> overestimated?

Jonas Rosendahl, Olfert Landt, Jana Bernadova, +14

Gut

Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis

Emmanuelle Masson, Jian‐Min Chen, Virginie Scotet, +2

Human Genetics

Pancreatic Fluid CollectionImmunologyGastroenterologyPathologyIdiopathic Chronic Pancreatitis +4

Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis

George A. Scheele, Diana C. Bartelt, Wilfried Bieger

Gastroenterology

Protein SecretionBiochemistryMedicineNatural SciencesBioanalysis +5