Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

David C. Whitcomb, Michael C. Gorry, Robert A. Preston et al. · Nature Genetics · 1996 · 1.6K citations

Medicine, Genetics, Molecular Genetics +12

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

Heiko Witt, W. A. P. Luck, Hans Christian Hennies et al. · Nature Genetics · 2000 · 1K citations

Medicine, Molecular Genetics, Pathology +5

SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis

Roland H. Pfützer, M. Michael Barmada, Andrew P. J. Brunskill et al. · Gastroenterology · 2000 · 514 citations · Full text

Medicine, Genetics, Molecular Genetics +10

Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis

MC Gorry, D Gabbaizedeh, William Furey et al. · Gastroenterology · 1997 · 476 citations · Full text

Medicine, Genetics, Molecular Genetics +7

A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis

Heiko Witt, W. A. P. Luck, Michael Becker · Gastroenterology · 1999 · 260 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +5