Concepedia

Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds

Hachiro Sugimoto, Youichi Iimura, Yoshiharu Yamanishi, Kiyomi Yamatsu

Bioorganic & Medicinal Chemistry Letters · 1992 · 67 citations · 5 references

DOI

Concepts

References

5

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

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Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives

Hachiro Sugimoto, Yutaka Tsuchiya, Hiroyuki Sugumi et al. · Journal of Medicinal Chemistry · 1990 · 84 citations · Full text

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Quantitative structure-activity relationship. QSAR, analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase

Mario Cardozo, Youichi Iimura, A. J. Hopfinger · Journal of Medicinal Chemistry · 1992 · 76 citations · Full text

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Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase

Mario Cardozo, Takatoshi Kawai, Youichi Iimura et al. · Journal of Medicinal Chemistry · 1992 · 65 citations · Full text

, , +17

Synthesis of 1‐benzyl‐4‐[(5,6‐dimethoxy[2‐<sup>14</sup>C]‐1‐indanon)‐2‐yl]‐methylpiperidine hydrochloride (E2020‐<sup>14</sup>C)

Youichi Iimura, Mannen MISHIMA, Hachiro Sugimoto · Journal of Labelled Compounds and Radiopharmaceuticals · 1989 · 19 citations

, , +10