Mild processing defect of porcine ΔF508-CFTR suggests that ΔF508 pigs may not develop cystic fibrosis disease

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

Seng H. Cheng, Richard J. Gregory, John Marshall et al. · Cell · 1990 · 1.8K citations

Life Sciences, Molecular Biology, Molecular Genetics +12

Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

Wilfried Dalemans, Pascal Barbry, Guy Champigny et al. · Nature · 1991 · 700 citations

Natural Sciences, Genetics, Molecular Genetics +13

Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis

Larry G. Johnson, John C. Olsen, Balázs Sarkadi et al. · Nature Genetics · 1992 · 435 citations

Medicine, Genetics, Molecular Biology +16

Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer

Christopher S. Rogers, Yanhong Hao, Tatiana Rokhlina et al. · Journal of Clinical Investigation · 2008 · 317 citations · Full text

Pharmacy, Molecular Biology, Molecular Genetics +17

Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists

Luis J. V. Galietta, Sujatha Jayaraman, A. S. Verkman · American Journal of Physiology-Cell Physiology · 2001 · 214 citations

Life Sciences, Cell Biology, Pharmacology +16