Disruption of the <i>CFTR</i> Gene Produces a Model of Cystic Fibrosis in Newborn Pigs

Christopher S. Rogers, David A. Stoltz, David K. Meyerholz, +25

Science

GeneticsImmunologyGastroenterologyPathologyMolecular Genetics +15

Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

David A. Stoltz, David K. Meyerholz, Alejandro A. Pezzulo, +28

Science Translational Medicine

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

Paola D. Vermeer, Lisa A. Einwalter, Thomas O. Moninger, +4

Nature

Signal TransductionDevelopmental BiologySignaling PathwayReceptor Tyrosine KinaseCell Growth +5

Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer

Christopher S. Rogers, Yanhong Hao, Tatiana Rokhlina, +17

Journal of Clinical Investigation

Cftr-δf508 Heterozygous PigsEngineeringMolecular BiologyAdeno-associated Virus–mediated GeneGene Delivery +17

Identification of a Bardet-Biedl syndrome locus on chromosome 3 and evaluation of an efficient approach to homozygosity mapping

Val C. Sheffield, Rivka Carml, Anne Kwltek-Black, +6

Human Molecular Genetics

The Δ <i>F508</i> Mutation Causes CFTR Misprocessing and Cystic Fibrosis–Like Disease in Pigs

Lynda S. Ostedgaard, David K. Meyerholz, Jeng-Haur Chen, +25

Science Translational Medicine

Inflammatory Lung DiseaseLung InflammationGeneticsPathologyMolecular Genetics +23

Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15

Rivka Carmi, Tatiana Rokhlina, Anne E. Kwitek, +4

Human Molecular Genetics

GeneticsGenetic EpidemiologyHuman PolymorphismPathologyDisease Gene Identification +18

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs

David A. Stoltz, Tatiana Rokhlina, Sarah E. Ernst, +27

Journal of Clinical Investigation

InflammationFibrosisLiver PhysiologyPhysiologyGastroenterology +10

Processing and function of CFTR-ΔF508 are species-dependent

Lynda S. Ostedgaard, Christopher S. Rogers, Qian Dong, +5

Proceedings of the National Academy of Sciences

A shortened adeno-associated virus expression cassette for <i>CFTR</i> gene transfer to cystic fibrosis airway epithelia

Lynda S. Ostedgaard, Tatiana Rokhlina, Philip H. Karp, +7

Proceedings of the National Academy of Sciences