Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

Abstract

Extracellular histones cause massive thromboembolism associated with consumptive coagulopathy, which is diagnostically indistinguishable from DIC. rTM binds to histones and neutralizes the prothrombotic action of histones. This may contribute to the effectiveness of rTM against DIC.