Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPARα antagonists

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Isabelle Issemann, Stephen Green · Nature · 1990 · 3.5K citations

Oxysterol, Biochemistry, Steroid Hormone Receptor +9

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Steven A. Kliewer, Scott S. Sundseth, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 1997 · 2.1K citations · Full text

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

H. Eric Xu, Thomas B. Stanley, Valerie G. Montana et al. · Nature · 2002 · 608 citations

Transcriptional Regulation, Biochemistry, Molecular Regulation +5

Differential Gene Regulation in Human Versus Rodent Hepatocytes by Peroxisome Proliferator-activated Receptor (PPAR) α

Jeffrey Lawrence, Ying Li, Shiying Chen et al. · Journal of Biological Chemistry · 2001 · 191 citations · Full text

Identification of a subtype selective human PPARα agonist through parallel-array synthesis

Peter J. Brown, L. William Stuart, Kevin P. Hurley et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 177 citations · Full text

Parallel-array Synthesis, Molecular Pharmacology, Drug Target +6