Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster

Hydroperoxide metabolism in mammalian organs.

B Chance, Helmut Sies, A Boveris · Physiological Reviews · 1979 · 5.8K citations

Biochemistry, Hydroperoxide Metabolism, Lipid Peroxidation +7

The Biologic Clock: The Mitochondria?

Denham Harman · Journal of the American Geriatrics Society · 1972 · 2K citations

Cell Death, Mitochondrial Biology, Redox Biology +17

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

Rajindar S. Sohal, Hung‐Hai Ku, Sanjiv Agarwal et al. · Mechanisms of Ageing and Development · 1994 · 785 citations

Lifespan Extension, Nutrition, Aging +12

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

Ian A. Trounce, Edward Byrne, Sangkot Marzuki · The Lancet · 1989 · 729 citations

Aging, Mitochondrial Function, Longevity +5

Energy Thresholds in Brain Mitochondria

Gavin P. Davey, S Peuchen, John B. Clark · Journal of Biological Chemistry · 1998 · 355 citations · Full text