Jab1 antagonizes TGF‐β signaling by inducing Smad4 degradation

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

Peter A. Kavsak, Richele K. Rasmussen, Carrie G. Causing et al. · Molecular Cell · 2000 · 1.3K citations · Full text

Molecular Physiology, Signal Transduction, E3 Ubiquitin Ligase +11

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

Leigh Zawel, Jia Le Dai, Phillip Buckhaults et al. · Molecular Cell · 1998 · 932 citations · Full text

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Haitao Zhu, Peter A. Kavsak, Shirin Abdollah et al. · Nature · 1999 · 842 citations

Developmental Biology, Cell Regulation, Smad Ubiquitin Ligase +7

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

Takanori Ebisawa, Minoru Fukuchi, Gyo Murakami et al. · Journal of Biological Chemistry · 2001 · 836 citations · Full text

Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome

Svetlana Lyapina, Gregory A. Cope, Anna Shevchenko et al. · Science · 2001 · 688 citations

Scf Complexes, Transcriptional Regulation, Signal Transduction +15