TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

Yi Tang, Xiangwei Wu, Weiqi Lei, +11

Nature Medicine

Regenerative MedicineMedicineTgf-β1–induced MigrationBone RepairBone Remodeling +8

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

Gehua Zhen, Chunyi Wen, Xiaofeng Jia, +18

Nature Medicine

Regenerative MedicineMesenchymal Stem CellsMedicineCartilage DegenerationOsteoarthritis +9

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

Hui Xie, Zhuang Cui, Long Wang, +17

Nature Medicine

Preosteoclasts Induces AngiogenesisDevelopmental BiologyAngiogenesisBone Morphogenic ProteinVascular Biology +6

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Lingling Xian, Xiangwei Wu, Lijuan Pang, +13

Nature Medicine

Regenerative MedicineMesenchymal Stem CellsDevelopmental BiologyBone Morphogenic ProteinMedicine +11

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

Shouan Zhu, Jianxi Zhu, Gehua Zhen, +25

Journal of Clinical Investigation

Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

Hao Chen, Bo Hu, Xiao Lv, +19

Nature Communications

SclerostinPeripheral NervesCellular PhysiologyOsteoporosisOrthopaedic Surgery +17

Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone

Zhuang Cui, Janet L. Crane, Hui Xie, +12

Annals of the Rheumatic Diseases

Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells

Xu Cao, Xiangwei Wu, Deborah A. Frassica, +11

Proceedings of the National Academy of Sciences

Adult Stem CellOsteoporosisBone Marrow MicroenvironmentOrthopaedic SurgeryRegenerative Medicine +20

Parathyroid hormone signaling through low-density lipoprotein-related protein 6

Mei Wan, Chaozhe Yang, Jun Li, +7

Genes & Development

Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice

Xiao Wang, Fengfeng Li, Liang Xie, +14

Nature Communications