l-Carnitine suppresses the onset of neuromuscular degeneration and increases the life span of mice with familial amyotrophic lateral sclerosis

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

D.R. Rosen, Teepu Siddique, David T. Patterson et al. · Nature · 1993 · 7K citations

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Neurological Disorder +7

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

Mark E. Gurney, Haifeng Pu, Arlene Y. Chiu et al. · Science · 1994 · 4.1K citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

Philip C. Wong, Carlos A. Pardo, David Borchelt et al. · Neuron · 1995 · 1.4K citations

Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1

Jiming Kong, Zuoshang Xu · Journal of Neuroscience · 1998 · 711 citations · Full text

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

M E Ripps, George W. Huntley, Patrick R. Hof et al. · Proceedings of the National Academy of Sciences · 1995 · 710 citations · Full text

Knockout Mouse, Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis +15