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Bioorganic & Medicinal Chemistry Letters · 2014 · 18 citations · 22 references
Open access
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryMolecular PharmacologyEnzyme InhibitionLigand BindingLigand-based DesignMolecular Docking
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Robbins and Cotran Pathologic Basis of Disease
Syed A. Hoda, Raza S. Hoda · American Journal of Clinical Pathology · 2020 · 3.4K citations
Life Sciences, Pathology, Clinical Medicine +4
BindingDB Entry 2025: Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
PubMed · 2007 · 462 citations · Full text
Medicine, Oncology, Pharmacology +15
A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.
Laura Sepp‐Lorenzino, Zhuang Ma, Elaine Rands et al. · PubMed · 1995 · 384 citations
Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.
Ming Liu, Matthew Bryant, Jianping Chen et al. · PubMed · 1998 · 309 citations
Medicine, Medicinal Chemistry, Pharmacology +15
Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones
Mark M. Moasser, Laura Sepp‐Lorenzino, Nancy E. Kohl et al. · Proceedings of the National Academy of Sciences · 1998 · 210 citations
Medicine, Oncology, Pharmacology +16