Concepedia

Publication | Closed Access

Development of HIV-1 resistance to (−)2′-deoxy-3′-thiacytidine in patients with AIDS or advanced AIDS-related complex

DOI

109

Citations

0

References

1995

Year

Mark A. Wainberg, Horacio Salomón, Zhengxian Gu, Julio Montaner, Timothy P. Cooley, Ronald P. McCaffrey, John Ruedy, Hilary M. Hirst, Nick Cammack, J. M. Cameron,
AIDS

Abstract

In vitro resistance to 3TC developed in a high proportion of subjects who received prolonged monotherapy with this drug. The development of resistance to 3TC was associated with appearance of mutated viral forms and the disappearance of wild-type virus, with regard to codon 184, in both patient plasma and PBMC.