Effect of UV Sunscreens Loaded in Solid Lipid Nanoparticles: A Combinated SPF Assay and Photostability

Abstract

The aim of this investigation was to obtain lipid nanoparticles loaded with different sunscreen agents in order to achieve enhanced photoprotection and to decrease the amount of UV – absorbers, with preserving at the same time a high sun protection factor. The developed formulations combined different types of additives including a mixture of non-ionic surfactant and lechitine with two lipids as solid matrix to obtain favourable stable lipid formulations. The research work could be concluded as successefully production of lipid nanoparticles loaded with UV-A and UV-B absorbers (with average size less than 100 nm) that may represent useful UV-blocking systems in sunscreen products for cosmetical purpose.