Heme oxygenase-1–mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice - Concepedia

Concepedia

Publication | Open Access

Heme oxygenase-1–mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice

DOI Full Paper Access

210

Citations

18

References

2011

Year

Evie H. Carchman, Jayashree Rao, Patricia Loughran, Matthew R. Rosengart, Brian S. Zuckerbraun

Abstract

Sepsis or LPS-induced autophagy protects against hepatocellular death, in part via an HO-1 p38 MAPK-dependent signaling. Further investigations are needed to elucidate how autophagic signaling prevents apoptosis and cell death.

References

	Year	Citations
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction Richard S. Hotchkiss, Paul E. Swanson, Bradley D. Freeman, Critical Care Medicine	1999	1.3K
Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis Sophie Brouard, Leo E. Otterbein, Josef Anrather, The Journal of Experimental Medicine	2000	976
Autophagy Protects against Sindbis Virus Infection of the Central Nervous System Anthony Orvedahl, Sarah MacPherson, Rhea Sumpter, Cell Host & Microbe Cell AutophagyMolecular VirologyPathogenesisAutophagyViral Pathogenesis	2010	543
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure David Brealey, S Karyampudi, Thomas S. Jacques, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology InflammationSevere SepsisMitochondrial FunctionMitochondrial DysfunctionSkeletal Muscle	2004	454
Heme oxygenase-1–derived carbon monoxide enhances the host defense response to microbial sepsis in mice Su Wol Chung, Xiaoli Liu, Alvaro A. Macias, Journal of Clinical Investigation	2008	319
Carbon monoxide signals <i>via</i> inhibition of cytochrome <i>c</i> oxidase and generation of mitochondrial reactive oxygen species Brian S. Zuckerbraun, Beek Yoke Chin, Martin Bilban, The FASEB Journal	2007	313
Carbon Monoxide Inhibition of Apoptosis during Ischemia-Reperfusion Lung Injury Is Dependent on the p38 Mitogen-activated Protein Kinase Pathway and Involves Caspase 3 Xuchen Zhang, Peiying Shan, Leo E. Otterbein, Journal of Biological Chemistry Acute Lung InjuryCarbon Monoxide InhibitionApoptosisImmunologyCell Death	2003	285
Carbon Monoxide Protects against Liver Failure through Nitric Oxide–induced Heme Oxygenase 1 Brian S. Zuckerbraun, Timothy R. Billiar, Sherrie L. Otterbein, The Journal of Experimental Medicine	2003	219
Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells Martin Uhl, Oliver Kepp, Hélène Jusforgues-Saklani, Cell Death and Differentiation Autoimmune DiseaseImmunologyAutophagyAntiviral ResponseVirology	2009	186
Mitochondrial dysfunction in sepsis David Brealey, Mervyn Singer Current Infectious Disease Reports InflammationMitochondrial FunctionMitochondrial DysfunctionPhysiologySepsis	2003	173

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