Concepedia

Novel ligands for the human histamine H1 receptor: Synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes

Ola M. Ghoneim, Jacqueline A. Legere, Alexander Golbraikh, Alexander Tropsha, Raymond G. Booth

Bioorganic & Medicinal Chemistry · 2006 · 44 citations · 40 references

DOI

Concepts

References

40

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins

Richard D. Cramer, David E. Patterson, Jeffrey D. Bunce · Journal of the American Chemical Society · 1988 · 3.9K citations

, , +14

Beware of q2!

Alexander Golbraikh, Alexander Tropsha · Journal of Molecular Graphics and Modelling · 2002 · 3.7K citations

Cyanohydridoborate anion as a selective reducing agent

Richard F. Borch, Mark D. Bernstein, H. D. Durst · Journal of the American Chemical Society · 1971 · 1.8K citations

, , +5

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

A. De Léan, Jeffrey M. Stadel, Robert J. Lefkowitz · Journal of Biological Chemistry · 1980 · 1.6K citations · Full text

, , +17