Journal of the American Chemical Society · 2001 · 74 citations · 5 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryOrganic SynthesisRetrosynthetic AnalysisAsymmetric SynthesisEnantioselective SynthesisRadical Cyclization
Total synthesis of the unnatural (-)-enantiomer of lasonolide A was achieved starting from ethyl l-malate. The two tetrahydropyranyl fragments were prepared stereoselectively via radical cyclization reactions of beta-alkoxyacrylates. The full structure of natural lasonolide A was determined unequivocally.
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Oxidative cleavage of silicon-carbon bonds in organosilicon fluorides to alcohols
Kohei Tamao, Toshio Kakui, Munetaka Akita et al. · Tetrahedron · 1983 · 193 citations