Journal of the American Chemical Society · 2003 · 148 citations · 16 references
Available DiacetoneBiosynthesisBioorganic ChemistryEngineeringBiochemistrySugar UnitsBiocatalysisNatural SciencesGlycobiologyHeparin OligosaccharidesPolysaccharideNatural Product SynthesisCarbohydrate-protein InteractionBiomolecular EngineeringGlycosylation
An efficient preparation of rare 2-O-benzoyl-3-O-benzyl-1,6-anhydro-β-l-idopyranose from commercially available diacetone α-d-glucose in five straightforward steps is described here. With this key building block in hand, the total syntheses of heparin oligosaccharides with three, five, seven, and nine sugar units are successfully carried out.
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Heparin Structure and Interactions with Basic Fibroblast Growth Factor
Salem Faham, Ronald E. Hileman, Jonathan R. Fromm et al. · Science · 1996 · 801 citations