Concepedia

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

Claudia Percivalle, Claudia Sissi, Maria Laura Greco, Caterina Musetti, Angelica Mariani, Anna Artese, Giosuè Costa, Maria Lucia Perrore, Stefano Alcaro, Mauro Freccero

Organic & Biomolecular Chemistry · 2014 · 35 citations · 53 references

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Abstract

Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties.

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