Concepedia

Decreased Total Lymphocyte Counts in Pancreatic Cancer: An Index of Adverse Outcome

Paola Fogar, Cosimo Sperti, Daniela Basso, M. Sanzari, Eliana Greco, Carla Davoli, Filippo Navaglia, Carlo‐Federico Zambon, Claudio Pasquali, Enzo Venza,

Pancreas · 2005 · 263 citations · 26 references

DOI

Abstract

The reduction of total lymphocytes in blood is the main immunologic change in advanced PC. The survival of these patients depends mainly on tumor stage, but it is also affected by the number of circulating lymphocytes, suggesting that the immune system plays an important role in pancreatic adenocarcinoma immunosurveillance and immunoediting.

References

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Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

Udaya Liyanage, Todd T. Moore, Hong‐Gu Joo et al. · The Journal of Immunology · 2002 · 1.5K citations

CD8+ Tumor-Infiltrating Lymphocytes Together with CD4+ Tumor-Infiltrating Lymphocytes and Dendritic Cells Improve the Prognosis of Patients with Pancreatic Adenocarcinoma

Akira Fukunaga, Masaki Miyamoto, Yasushi Cho et al. · Pancreas · 2003 · 522 citations

Mesothelin-specific CD8+ T Cell Responses Provide Evidence of In Vivo Cross-Priming by Antigen-Presenting Cells in Vaccinated Pancreatic Cancer Patients

Amy Thomas, Lynn M. Santarsiero, Eric R. Lutz et al. · The Journal of Experimental Medicine · 2004 · 347 citations · Full text

Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy

Charalambos Gogos, Panayiotis Ginopoulos, Bassilis Salsa et al. · Cancer · 1998 · 310 citations

Systemic and local immunosuppression in pancreatic cancer patients.

Wolfram von Bernstorff, Martina Voss, Susanne Freichel et al. · PubMed · 2001 · 281 citations

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