Blockade of costimulatory pathway with alliance therapy of CTLA4Ig and ICOSIg alleviated autoimmune damage in EAM and improved cardiac function. The mechanisms may be downregulation of costimulatory molecules and anti-inflammation.
20
ICOS co-stimulatory receptor is essential for T-cell activation and function
Chen Dong, Amy E. Juedes, Ulla Angela Temann et al. · Nature · 2001 · 928 citations
Signal Transduction, Adaptive Immune System, T-regulatory Cell +12