Characterization of a Panel of Cell Lines Derived From Urothelial Neoplasms: Genetic Alterations, Growth In Vivo and the Relationship of Adenoviral Mediated Gene Transfer to Coxsackie Adenovirus Receptor Expression

Abstract

Our panel of 10 human urothelial cell lines differed in genetic alterations, growth in nude mice, susceptibility to adenoviral mediated gene transduction, and expression of p53, p16 and pRB. The availability of various urothelial cancer cell lines with differing genotypic and phenotypic features will facilitate further research into bladder cancer.