Effects of Abeta_1–42 on the current of K_ATP channels in cultured cholinergic neurons

Abstract

It is concluded that Abeta(1-42) inhibits the openings of the K(ATP) channels, while this inhibitory action can be removed by pretreatment with Diazoxide. It is indicated that the opening of K(ATP) channels may play a potential neuroprotective role in antineurotoxicity of Abeta(1-42), and the application of Diazoxide in small dose may be helpful in the treatment of Abeta(1-42) neurotoxicity.