Methylation status of differentially methylated regions at Igf2/H19 locus in porcine gametes and preimplantation embryos

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

Marianne Frommer, Louise E. McDonald, David Millar et al. · Proceedings of the National Academy of Sciences · 1992 · 3.3K citations

Life Sciences, Genetics, Molecular Biology +14

High sensitivity mapping of methylated cytosines

J.CIark Susan, Cheryl Paul, Marianne Frommer · Nucleic Acids Research · 1994 · 1.9K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos

Wendy Dean, Fátima Santos, Miodrag Stojković et al. · Proceedings of the National Academy of Sciences · 2001 · 974 citations · Full text

Life Sciences, Biology, Developmental Biology +17

Active demethylation of the paternal genome in the mouse zygote

Joachim Oswald, Sabine Engemann, Natasha Lane et al. · Current Biology · 2000 · 962 citations

Life Sciences, Genetics, Molecular Biology +16

Bisulfite genomic sequencing: systematic investigation of critical experimental parameters

Christoph Grunau · Nucleic Acids Research · 2001 · 799 citations · Full text

Life Sciences, Genetics, Molecular Biology +17