Epicutaneously applied <scp>D</scp>er p 2 induces a strong <scp>T_H</scp>2‐biased antibody response in <scp>C</scp>57<scp>BL</scp>/6 mice, independent of functional <scp>TLR</scp>4

Abstract

Our data suggest that rDer p 2 alone can cause a strong TH 2-biased response via the skin being enhanced in the presence of LPS. This response is not reliant on functional TLR4, but vice versa TLR4 expression rather protects against epicutaneous sensitization to house dust mite allergen Der p 2.