Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

Richard E. Heikkila, Lawrence Manzino, Felicitas S. Cabbat et al. · Nature · 1984 · 1K citations

Medicine, Neuroscience, Pharmacology +14

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

Sanford P. Markey, Jan N. Johannessen, Chuang C. Chiueh et al. · Nature · 1984 · 780 citations

Medicine, Neuroscience, Pharmacology +11

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: characterization and localization of receptor binding sites in rat and human brain.

Jonathan A. Javitch, G R Uhl, S H Snyder · Proceedings of the National Academy of Sciences · 1984 · 121 citations · Full text

Life Sciences, Neuroscience, Pharmacology +12

High-affinity binding sites for [3H]MPTP may correspond to monamine oxidase

Bruce Parsons, Thomas C. Rainbow · European Journal of Pharmacology · 1984 · 93 citations

Life Sciences, Biochemistry, Pharmacology +9