Jonathan A. Javitch

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

Jonathan A. Javitch, Robert J. D’Amato, Stephen M. Strittmatter et al. · Proceedings of the National Academy of Sciences · 1985 · 1.3K citations · Full text

Parkinsonism-inducing Neurotoxin, Neurotransmitter, Dopamine Neurons +17

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Ellen Y. T. Chien, Wei Liu, Qiang Zhao et al. · Science · 2010 · 1.1K citations

Molecular Pharmacology, Crystal Structure, Ionic Lock +15

Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6

Juan Antonio Ballesteros‐Cánovas, Anne D. Jensen, George Liapakis et al. · Journal of Biological Chemistry · 2001 · 616 citations · Full text

Ionic Lock, Transmembrane Segments 3, Synaptic Transmission +25

Structural Mimicry in G Protein-Coupled Receptors: Implications of the High-Resolution Structure of Rhodopsin for Structure-Function Analysis of Rhodopsin-Like Receptors

Juan Antonio Ballesteros‐Cánovas, Lei Shi, Jonathan A. Javitch · Molecular Pharmacology · 2001 · 440 citations

β2 Adrenergic Receptor Activation

Lei Shi, George Liapakis, Rui Xu et al. · Journal of Biological Chemistry · 2002 · 420 citations · Full text