Knockdown of the bovine prion gene PRNP by RNA interference (RNAi) technology

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.1K citations

Specific Genetic Interference, Natural Sciences, Genetics +9

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.3K citations

Natural Sciences, Rna Splicing, Rna Biology +9

Role for a bidentate ribonuclease in the initiation step of RNA interference

Emily Bernstein, Amy A. Caudy, Scott M. Hammond et al. · Nature · 2001 · 4.9K citations

Rna Interference, Genetics, Natural Sciences +12

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

Scott M. Hammond, Emily Bernstein, David Beach et al. · Nature · 2000 · 3K citations

Chromatin, Transcriptional Regulation, Developmental Biology +9

Asymmetry in the Assembly of the RNAi Enzyme Complex

Dianne S. Schwarz, György Hutvàgner, Tingting Du et al. · Cell · 2003 · 2.8K citations · Full text

Natural Sciences, Rna Structure Prediction, Dna Replication +4