Concepedia

Tenuifolin, an extract derived from <i>tenuigenin</i>, inhibits amyloid‐β secretion <i>in vitro</i>

Jianlu Lv, Honglin Jia, Yong Jiang, Yuting Ruan, Z. Liu, Wenhui Yue, Konrad Beyreuther, Peng‐Fei Tu, D. Zhang

Acta Physiologica · 2009 · 72 citations · 16 references

DOI

Abstract

Tenuifolin is an effective compound from tenuigenin. We believe that this finding should lead the way for future experiments to determine the exact mechanism for tenuifolin's effect on Abeta secretion.

References

16

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1K citations

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Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice

Radosveta Koldamova, Matthias Staufenbiel, Iliya Lefterov · Journal of Biological Chemistry · 2005 · 353 citations · Full text

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1

Masuo Ohno, Lei Chang, Wilbur Tseng et al. · European Journal of Neuroscience · 2006 · 301 citations

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Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture

Daniel Skovronsky, Robert W. Doms, Virginia M.‐Y. Lee · The Journal of Cell Biology · 1998 · 290 citations · Full text

Novel cognitive improving and neuroprotective activities of <i>Polygala tenuifolia</i> Willdenow extract, BT‐11

Cheol Hyoung Park, Se Hoon Choi, Ja‐Wook Koo et al. · Journal of Neuroscience Research · 2002 · 131 citations