Mitochondrial point mutations do not limit the natural lifespan of mice

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Aleksandra Trifunović, Anna Wredenberg, Maria Falkenberg et al. · Nature · 2004 · 2.7K citations

Aging, Mitochondrial Function, Longevity +3

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

Gregory C. Kujoth, Asimina Hiona, Thomas D. Pugh et al. · Science · 2005 · 2.1K citations

Aging, Mitochondrial Function, Mitochondrial Dynamic +12

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

Samuel E. Schriner, Nancy J. Linford, George M. Martin et al. · Science · 2005 · 1.7K citations

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Andreas Bender, Kim J. Krishnan, Christopher M. Morris et al. · Nature Genetics · 2006 · 1.6K citations

Mitochondrial Function, Mitochondrial Dynamic, Genetics +8

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

Yevgenya Kraytsberg, Elena Kudryavtseva, Ann C. McKee et al. · Nature Genetics · 2006 · 892 citations

Mitochondrial Function, Genetics, Degenerative Pathology +6