Concepedia

Coding Polymorphisms in the Parkin Gene and Susceptibility to Parkinson Disease

Christoph-Burkhard Lücking, Véronique Chesneau, Ebba Lohmann, Patrice Verpillat, Cyprien Dulac, Francesca Gasparini, Yves Agid, Alexandra Dürr, Alexis Brice

Archives of Neurology · 2003 · 54 citations · 13 references

DOI

Abstract

Some parkin polymorphisms appear to be risk factors for sporadic or familial PD. The functional effects of these coding polymorphisms need to be established, and further studies on parkin polymorphisms in PD should be undertaken.

References

13

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature · 1998 · 5.2K citations

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Hideki Shimura, Nobutaka Hattori, Shinichiro Kubo et al. · Nature Genetics · 2000 · 2K citations

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Association between Early-Onset Parkinson's Disease and Mutations in the<i>Parkin</i>Gene

Christoph B. Lücking, Alexandra Dürr, Vincenzo Bonifati et al. · New England Journal of Medicine · 2000 · 1.4K citations · Full text

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

Yuzuru Imai, Mariko Soda, Haruhisa Inoue et al. · Cell · 2001 · 1.1K citations · Full text

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Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy

Mary V. Baker, Irene Litvan, Henry Houlden et al. · Human Molecular Genetics · 1999 · 793 citations · Full text