Transition Metal-Mediated Liposomal Encapsulation of Irinotecan (CPT-11) Stabilizes the Drug in the Therapeutically Active Lactone Conformation

Comprehensive Coordination Chemistry

Colin Eaborn · Journal of Organometallic Chemistry · 1988 · 7.2K citations

Inorganic Chemistry, Coordination Complex, Comprehensive Coordination Chemistry +2

Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer

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Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential

Michael J. Hope, Marcel B. Bally, G. A. Webb et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1985 · 2.1K citations

Membrane Structure, Membrane Potential, Engineering +8

Irinotecan plus Cisplatin Compared with Etoposide plus Cisplatin for Extensive Small-Cell Lung Cancer

Kazumasa Noda, Yutaka Nishiwaki, Masaaki Kawahara et al. · New England Journal of Medicine · 2002 · 1.4K citations · Full text

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

Y H Hsiang, M G Lihou, Leroy F. Liu · PubMed · 1989 · 1K citations

Chromatin, Genome Instability, Fork Breakage +9