Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.5K citations

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

Toll-like Receptors, Virulence Factor, Pathogenesis +7

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

Host Response, Toll-like Receptors, Signal Transduction +10

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Bruno Lemaître, Émmanuelle Nicolas, Lydia Michaut et al. · Cell · 1996 · 3.9K citations · Full text

Biology, Potent Antifungal Response, Natural Sciences +10

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Fumitaka Hayashi, Kelly D. Smith, Adrian Ozinsky et al. · Nature · 2001 · 3.5K citations

Host Response, Toll-like Receptors, Bacterial Flagellin +11