Concepedia

Lamivudine in combination with zidovudine, stavudine, or didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial

Daniel R. Kuritzkes, Ian C. Marschner, Victoria A. Johnson, Roland L. Bassett, Joseph J. Eron, Margaret A. Fischl, Robert L. Murphy, Kenneth H. Fife, Janine Maenza, Mary E. Rosandich,

AIDS · 1999 · 47 citations · 24 references

DOI

Abstract

3TC added significantly to the virologic effects of d4T, but not ddl, in treatment-naive patients. 3TC plus d4T produced virologic changes comparable to those of 3TC plus ZDV. These results support the use of 3TC with either ZDV or d4 as a component of initial combination antiretroviral therapy.

References

24

Practical Statistics for Medical Research.

Sophie Walter, Daniel Altman · Biometrics · 1992 · 11.7K citations

, , +1

A Trial Comparing Nucleoside Monotherapy with Combination Therapy in HIV-Infected Adults with CD4 Cell Counts from 200 to 500 per Cubic Millimeter

Scott M. Hammer, David Katzenstein, Michael D. Hughes et al. · New England Journal of Medicine · 1996 · 1.1K citations · Full text

Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination Therapy

Brendan Larder, Sharon D. Kemp, P. Richard Harrigan · Science · 1995 · 633 citations

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.

Margaret Tisdale, Sharon D. Kemp, N. R. Parry et al. · Proceedings of the National Academy of Sciences · 1993 · 607 citations · Full text

, , +15

Treatment with Lamivudine, Zidovudine, or Both in HIV-Positive Patients with 200 to 500 CD4+ Cells per Cubic Millimeter

Joseph J. Eron, Sharon L. Benoit, Joseph G. Jemsek et al. · New England Journal of Medicine · 1995 · 538 citations · Full text