Phosphopeptide Screen Uncovers Novel Phosphorylation Sites of Nedd4-2 That Potentiate Its Inhibition of the Epithelial Na+ Channel

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

Olivier Staub, Sascha E. Dho, P Henry et al. · The EMBO Journal · 1996 · 841 citations · Full text

Nedd4 Bind, Protein Function, Molecular Physiology +12

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na+ channel cell surface expression

Christophe Debonneville · The EMBO Journal · 2001 · 701 citations · Full text

Signal Transduction, Molecular Physiology, Signaling Pathway +8

(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms

Florian Läng, Christoph Böhmer, Mònica Palmada et al. · Physiological Reviews · 2006 · 683 citations

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

Jongsun Park · The EMBO Journal · 1999 · 554 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +9

A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

Zhou Songyang, Kun Ping Lu, Young T. Kwon et al. · Molecular and Cellular Biology · 1996 · 550 citations · Full text

Molecular Biology, Protein Kinase A, Signaling Pathway +20