The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

Howard A. Burris, Malcolm J. Moore, John Sahl Andersen et al. · Journal of Clinical Oncology · 1997 · 5.8K citations

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Rajnish A. Gupta, Nilay Shah, Jeewon Kim et al. · Nature · 2010 · 5.2K citations · Full text

Non-coding Rna Hotair, Chromatin, Engineering +14

Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs

John L. Rinn, Michael A. Kertesz, Jordon K. Wang et al. · Cell · 2007 · 4.2K citations · Full text

Chromatin, Systems Biology, Engineering +12

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

Ahmad M. Khalil, Mitchell Guttman, Maite Huarte et al. · Proceedings of the National Academy of Sciences · 2009 · 2.8K citations · Full text

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

Yul W. Yang, Amartya Sanyal, M. Ryan Corces et al. · Nature · 2011 · 2K citations · Full text

Histone Modifications, Genetics, Epigenetics +16