Pesticide Science · 1986 · 11 citations · 13 references
PharmacyPharmacokineticsToxicologyBioavailabilityPesticide ToxicologyToxicokineticsChemical Contaminants In MilkMilk ContaminantsPesticide Residue AnalysisPesticide ResiduesResidue ToxicologyVeterinary Drug ResiduesContaminant Fate In MilkDrug Residues In MilkEquilibriumMilk ResiduesResidue Depletion KineticsResidues In Animal ProductsToxicant Kinetics During LactationTransfer Coefficient
Abstract Three groups of buffaloes were fed with 20, 100 and 400 mg of p,p ′‐DDT in their daily rations. The DDT residues in the milk fat of the treated animals showed an initial rapid rise but soon attained a dose‐dependent equilibrium. The transfer coefficient of DDT residues in milk at ‘plateau’ levels showed an average value of about 12%. Half‐life values for the rate of decline of DDT residues during the post‐dosing period were computed according to a two‐open‐compartment model. Dermal application of p,p ′‐DDT to buffaloes also resulted in excretion of a significant amount of its residues in milk. TDE was the predominant compound present in milk when buffaloes had ingested p,p ′‐DDT, whilst p,p ′‐DDT itself was present in greater quantity than its metabolites when animals were treated dermally.
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Lactational Output of DDT Fed Prepartum to Dairy Cattle
R.C. Laben, T. E. Archer, Donald G. Crosby et al. · Journal of Dairy Science · 1965 · 50 citations · Full text