α-Difluoromethylornithine (DFMO) as a Potent Arginase Activity Inhibitor in Human Colon Carcinoma Cells

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

Anthony E. Pegg · PubMed · 1988 · 1.5K citations

Chemoprevention Strategy, Pathology, Pharmaceutical Chemistry +18

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

Brian W. Metcalf, Philippe Bey, Charles Danzin et al. · Journal of the American Chemical Society · 1978 · 1K citations

Drug Target, Altmetric Attention Score, Chemical Biology +19

Ornithine decarboxylase activity is critical for cell transformation

Merja Auvinen, Aino Paasinen, Leif C. Andersson et al. · Nature · 1992 · 631 citations · Full text

Biosynthesis, Cellular Enzymology, Cellular Biochemistry +3

Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT‐29 selected for growth in sugar‐free medium and its inhibition by glucose

A Zweibaum, Moı̈se Pinto, Guillemette Chevalier et al. · Journal of Cellular Physiology · 1985 · 340 citations

Gastroenterology, Pathology, Cell Culture +22

Rat Liver Arginase: Kinetic Mechanism, Alternate Substrates, and Inhibitors

Robert S. Reczkowski, David E. Ash · Archives of Biochemistry and Biophysics · 1994 · 167 citations

Biochemistry, Medicine, Liver Physiology +5