Diastereoselective Zinc‐Mediated Barbier‐Type Allylation and Propargylation of 3‐Formylcephalosporins

Abstract

Abstract We describe the allylation and propargylation of 3‐formylcephalosporins under zinc‐mediated, aqueous Barbier conditions, from which the corresponding homoallylic alcohols are produced in good yields and with good‐to‐excellent diastereoselectivity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)