B-Lymphoma cells with epigenetic silencing of Pax5 trans-differentiate into macrophages, but not other hematopoietic lineages

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

Edward W. Scott, M. Celeste Simon, John Anastasi et al. · Science · 1994 · 1.5K citations

Knockout Mouse, Cell Lineage, Transcription Factor Pu.1 +15

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

Stephen L. Nutt, Barry Heavey, Antonius Rolink et al. · Nature · 1999 · 1.2K citations

Lymphoid Neoplasia, Transcriptional Regulation, B-lymphoid Lineage +9

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

Scott R. McKercher, Bruce E. Torbett, Kenton L. Anderson et al. · The EMBO Journal · 1996 · 1.1K citations · Full text

Laboratory Hematology, Multiple Hematopoietic Abnormalities, Genetic Disorder +10

Stepwise Reprogramming of B Cells into Macrophages

Huafeng Xie, Min Ye, Ru Feng et al. · Cell · 2004 · 930 citations · Full text

Adaptive Immune System, Immunology, B Cells +4

Multilineage gene expression precedes commitment in the hemopoietic system.

Manli Hu, Diane S. Krause, M. F. Greaves et al. · Genes & Development · 1997 · 747 citations · Full text

Hemopoietic System, Gene Activity, Cell Specialization +16