Extracellular HMGB1 Released by NMDA Treatment Confers Neuronal Apoptosis via RAGE-p38 MAPK/ERK Signaling Pathway

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Paola Scaffidi, Tom Misteli, Marco E. Bianchi · Nature · 2002 · 4.1K citations

Inflammation, Chromatin, Cytokine +10

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Haichao Wang, Ona Bloom, Minghuang Zhang et al. · Science · 1999 · 3.4K citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Shi Du Yan, Xi Chen, Jin Fu et al. · Nature · 1996 · 2K citations

Neurodegenerative Diseases, Alzheimer's Disease, Neurology +4

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Jane Tian, Ana M. Avalos, Su-Yau Mao et al. · Nature Immunology · 2007 · 1.3K citations

Inflammation, Toll-like Receptors, Molecular Immunology +11

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

Tiziana Bonaldi · The EMBO Journal · 2003 · 1.2K citations · Full text

Chromatin, Protein Secretion, Cell Regulation +8