Phase I clinical trial of recombinant human tumor necrosis factor

An endotoxin-induced serum factor that causes necrosis of tumors.

E A Carswell, Lloyd J. Old, Robert Kassel et al. · Proceedings of the National Academy of Sciences · 1975 · 4.5K citations · Full text

Inflammation, Residual Endotoxin, Tumor Necrosis Factor +15

Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor

Takashi Shirai, Hiroshi Yamaguchi, Hirataka Ito et al. · Nature · 1985 · 459 citations

Virulence Factor, Pathogenesis, Bacteriology +8

Phase I study of recombinant tumor necrosis factor in cancer patients.

Mark Blick, Stephen A. Sherwin, Michael G. Rosenblum et al. · PubMed · 1987 · 428 citations

Immunology, Immunoediting, Pathology +19

LAGRAN program for area and moments in pharmacokinetic analysis

Mario L. Rocci, William J. Jusko · Computer Programs in Biomedicine · 1983 · 415 citations

Pharmacodynamics, Medicine, Bioanalysis +5