HPLC with carbohydrate carbamate chiral phases: Influence of chiral phase structure on enantioselectivity

Abstract

Abstract The enantioselective resolution of trans ‐stilbene oxide and of 23 chiral sulfoxides was investigated on cellulose and amylose tris(arylcarbamate) stationary phases coated on aminopropylated 7 μm spherical silica with 500 Å diameter pores. Cellulose tris‐(3,5 dimethylphenylcarbamate) showed good resolving power for many of the sulfoxides and amylose tris‐(3,5 dimethoxyphenylcarbamate) showed advantages for the resolution of certain sulfoxides which were not separated on other phases. © 1994 Wiley‐Liss, Inc.