Concepedia

Hedgehog antagonist GDC‐0449 is effective in the treatment of advanced basal cell carcinoma

Shivan Amin, Raoul Tibes, Ji‐Eon Kim, C. Patrick Hybarger

The Laryngoscope · 2010 · 29 citations · 6 references

DOI

Abstract

GDC-0449 showed significant inhibitory activity in the treatment of advanced basal cell carcinoma.

References

6

Incidence Estimate of Nonmelanoma Skin Cancer in the United States, 2006

Howard W. Rogers, Martin A. Weinstock, Ashlynne R. Harris et al. · Archives of Dermatology · 2010 · 1.2K citations · Full text

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

Daniel D. Von Hoff, Patricia LoRusso, Charles M. Rudin et al. · New England Journal of Medicine · 2009 · 1.1K citations · Full text

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

Charles M. Rudin, Christine L. Hann, John Laterra et al. · New England Journal of Medicine · 2009 · 1K citations · Full text

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The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

Mae R. Gailani, Mona Ståhle‐Bäckdahl, David J. Leffell et al. · Nature Genetics · 1996 · 771 citations

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Hedgehog Pathway Inhibitor HhAntag691 Is a Potent Inhibitor of ABCG2/BCRP and ABCB1/Pgp

Yimao Zhang, John Laterra, Martin G. Pomper · Neoplasia · 2009 · 74 citations · Full text